Rising COVID-19 case counts in early 2020 led to changes in the data collection procedures used for the Current Population Survey/Housing Vacancy Survey (CPS/HVS), an important source of information about vacancy rates and the homeownership rate in the United States. On March 20th, 2020, the Census Bureau suspended in-person data collection attempts and shifted all data collection operations to telephone-based attempts, a change that remained in place through July 2020, when in-person data collection was gradually reintroduced in some areas of the country. This paper examines the implications of these data collection changes for CPS/HVS estimates. First, the paper presents a series of non-response analyses that use supplemental data sources to describe differences between responding and non-responding housing units, as well as the change in these differences over time. The non-response analyses find significant changes in these non-response outcomes beginning in the second quarter of 2020. Second, the paper develops an alternative non-response weighting adjustment factor and examines the implications for CPS/HVS estimates of the homeownership rate, rental vacancy rate, homeowner vacancy rate, and gross vacancy rate. The results suggest that the observed changes in non-response outcomes likely contributed to the historically large increase in the homeownership rate for the second quarter of 2020. While the vacancy rate estimates are not similarly sensitive to the alternative non-response weighting adjustment, the results illustrate the potential for the CPS/HVS vacancy rates in 2020 to underestimate the actual levels of vacancy due to the CPS/HVS weighting methodology’s assumption that all non-responding housing units are occupied. These results suggest that the CPS/HVS estimates of vacancy rates and the homeownership rate should be interpreted with caution until data collection operations return fully to their standard procedures.